Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique

  • Ahmed S. Abdul Jabbar


The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone  s630 was utilized. The HME raltegravir was formulated into tablet by direct compression method. The prepared tablets were assessed for all pre and post-compression parameters. The drug- excipients interaction was examined by FTIR and DSC. All formulas displayed complying with pharmacopoeial measures. The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir.

Keywords: Hot melt extrusion, Raltegravir, Plasdone S630.

Jun 4, 2018
How to Cite
S. ABDUL JABBAR, Ahmed. Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique. Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), [S.l.], v. 27, n. 1, p. 20-29A, june 2018. ISSN 1683-3597. Available at: <http://bijps.com/index.php/bijps/article/view/768>. Date accessed: 16 dec. 2018. doi: http://dx.doi.org/10.31351/vol27iss1pp20-29A.