Preparation and characterization of timed drug delivery system of sumatriptan using natural polymers

  • Mina Shihab Al-anbagi Baghdad
  • Nawal A. Rajab
  • Yehia I.Khalil

Abstract

Pulsatile drug delivery systems are time-controlled dosage forms which are designed to release the active pharmaceutical ingredient after a predetermined lag time to synchronize the disease circadian rhythm. A migraine shows circadian rhythm with a marked increase in attacks between 6 a.m. and 8 a.m.


Sumatriptan is a selective agonist at serotonin (5-Hydroxy tryptamine1  (5-HT1))receptors, is an effective treatment for acute migraine attacks.


The aim of this work is to prepare time-controlled press-coated tablet with a lag time of 5.45 hrs.


Six formulas of fast dissolving core tablets and three formulas of press-coated tablets were prepared by using direct compression method using different variables to prepare core tablets which include: different types and concentrations of superdisintegrants While different concentrations of natural and synthetic polymers were utilized in the preparation of press-coated tablets.


The obtained results showed that formula  F4 of core tablet, which contained 25 mg of sumatriptan, 5% w/w sodium starch glycolate and avicel PH 102 as the diluent, was the selected formula that gave the fastest and complete release of sumatriptan. Also, formula C3 of the press-coated tablet, which contained pectin: EC100 mpa.s: HPMCK15M in concentration30mg: 10mg:160mg respectively, was selected as the best coating layer since it gave 5.45  hours lag time.

Published
Jun 5, 2018
How to Cite
AL-ANBAGI, Mina Shihab; A. RAJAB, Nawal; I.KHALIL, Yehia. Preparation and characterization of timed drug delivery system of sumatriptan using natural polymers. Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), [S.l.], v. 27, n. 1, p. 89-99, june 2018. ISSN 1683-3597. Available at: <http://bijps.com/index.php/bijps/article/view/754>. Date accessed: 16 dec. 2018. doi: http://dx.doi.org/10.31351/vol27iss1pp89-99.